Fabrication and Characterization of a Porous TiO₂-Modified PEEK Scaffold with Enhanced Flexural Compliance for Bone Tissue Engineering.

ABSTRACT: Bone pathologies are becoming increasingly prevalent with an aging population, often necessitating bone grafting procedures. The current gold standard for grafting uses autologous tissue; however, this approach carries limitations such as donor site morbidity. Consequently, there is a growing interest in alternative biomaterials. Polyetheretherketone (PEEK), a thermoplastic with bone-like mechanical properties, has shown promise, although its limited bioactivity remains a critical constraint. Various functionalization strategies have been employed to enhance the biological performance of otherwise inert materials. This study aims to develop a functionalized porous PEEK scaffold to improve bioactivity of the material, thereby promoting human osteoblast (HOB) adhesion, proliferation, and dif

SUBMITTER: Galea Mifsud M 

PROVIDER: S-EPMC12522093 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature