Carnosine Biofunctionalized Hydroxyapatite Induces Copper-Driven Osteogenesis and Angiogenesis, Strengthening Its Bone Regenerative Capacities.

ABSTRACT: Hydroxyapatite (Hap) is a prominent biomaterial used as an effective implant material in bone tissue engineering, but its use presents some points of weakness in bone regeneration efficiency. Different biofunctionalization strategies have been utilized to increase the regenerative Hap capacities. Carnosine (Car) or β-alanyl-l-histidine dipeptide has received much attention due to its beneficial effects in osteoarticular diseases and bone tissue healing. Hap functionalized in noncovalent mode with Car at a nominal Ca:Car molar ratio (10:1, 2:1, and 1:1) was synthesized. The Hap-Car composites were characterized by using X-ray diffraction, scanning electron microscopy, and Fourier transform infrared spectroscopies. The structural and morphological feature comparisons indicate a similarity be

SUBMITTER: Naletova I 

PROVIDER: S-EPMC12522101 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature