Activation and Functionalization of Organic Disulfides by Bis(Perfluoroalkyl) Complexes of Nickel(II).

ABSTRACT: The [(MeCN)₂Ni-(R_f)₂] platform was used to study the oxidative addition of 8,8'-diquinolyl disulfide. The oxidative addition proceeds to afford [Ni-(R_f)₂(SR)₂] intermediates, which then eliminate R_aryl-S-R_fluoroalkyl products through consecutive carbon-sulfur bond-forming steps. The high-valent states of the nickel complexes are required to reductively eliminate the cross-coupled product, and it was shown through stoichiometric reactions that both the singly and doubly oxidized states can trigger the S-C_{perfluoroalkyl} bond forming reductive eliminations. These results show that such metal-mediated coupling reactions are viable and worthy of consideration in new methods development.

SUBMITTER: Ravidas CMT 

PROVIDER: S-EPMC12522123 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature