Hofmeister-Driven Ion Pairing in Monovalent Salts Directs Fibrinogen Nanofiber Assembly during Drying.

ABSTRACT: Fibrinogen nanofiber scaffolds hold promise for tissue engineering and wound healing due to their similarity to fibrin clots. We studied how alkaline salts (Na⁺, K⁺) influence fibrinogen precipitation during drying of highly saline dispersions. In situ roughness (Aq) monitoring revealed coprecipitation of salts and fibrinogen. SEM and Aq mapping showed morphologies from smooth (KCl) and faintly fibrous (NaCl) to highly rough and finely fibrous (Na-PO₄, K-PO₄). FTIR indicated that secondary structure changes are not always linked to fiber formation. XPS showed a stronger Na⁺ uptake, especially with fiber-forming salts. With Na⁺ and oxygen-containing polyvalent anions, kosmotropic SO₄^2- induced

SUBMITTER: Stamboroski S 

PROVIDER: S-EPMC12522127 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature