Assessing the Mechanism of Action of Synthetic Nanoengineered Antimicrobial Polymers against the Bacterial Membrane of <i>Pseudomonas aeruginosa</i>.

ABSTRACT: The lack of appropriate antimicrobials to tackle multidrug-resistant Gram-negative bacteria poses an escalating threat to modern medicine. Addressing this urgent issue, we have recently developed synthetic nanoengineered antimicrobial polymers (SNAPs), inspired by the physicochemical properties of antimicrobial peptides. Our findings have demonstrated that SNAPs are potent antimicrobial agents characterized by low toxicity and cost-effective large-scale production. In this study, we elucidate the mechanism of action of two distinct SNAPs, which vary in length and charge distribution. Focusing on the Gram-negative pathogen Pseudomonas aeruginosa LESB58, a hypervirulent strain prevalent in cystic fibrosis patients, we employ advanced high-resolution imaging techniques and neutron refl

SUBMITTER: Garcia Maset R 

PROVIDER: S-EPMC12522136 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature