Photodecarboxylation of the Siderophore Aerobactin with the Lewis Acidic Metal Ions Fe(III), Ga(III), and Ti(IV).

ABSTRACT: The class of α-hydroxy carboxylic acid-containing ferric siderophore natural products undergo photochemical modification by decarboxylation. To date, there is only limited mechanistic understanding of the metal-ion-mediated photodegradation of photoactive siderophores. This study investigates the photoreactivity of the α-hydroxy carboxylic acid-containing siderophore aerobactin (AB) and the corresponding Ga³⁺ and Ti⁴⁺ metal complexes in direct comparison with their Fe³⁺-bound counterpart. Using UV-vis and nuclear magnetic resonance (NMR) spectroscopy, complemented by time-dependent density functional theory (TD-DFT) calculations, we demonstrate that ligand-to-metal charge transfer (LMCT)-driven photocleavage of aerobactin-metal complexes is feasible beyond

SUBMITTER: Amason EK 

PROVIDER: S-EPMC12522143 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature