Catalytic asymmetric synthesis of indole-based atropisomers bearing silicon-stereogenic centers.

ABSTRACT: The first diastereo- and enantioselective synthesis of indole-based atropisomers bearing Si-stereogenic centers has been established via the strategy of catalytic asymmetric reductive silylation. By this strategy, a wide range of indole-based atropisomers bearing Si-stereogenic centers were synthesized in moderate to good yields with overall excellent enantioselectivities and good diastereoselectivities (up to 87% yield, 94% ee, 7.3 : 1 dr). This work not only provides a new strategy for catalytic asymmetric synthesis of atropisomers bearing Si-stereogenic centers, but also has realized the first catalytic asymmetric synthesis of indole-based atropisomers with a Si-stereogenic center, which will add an important member to the family of indole-based atropisomers bearing multiple chir

SUBMITTER: Liu SY 

PROVIDER: S-EPMC12522152 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature