Activity-dependent muscarinic signalling regulates presynaptic PKC pathway and neurotransmission machinery at the neuromuscular junction.

ABSTRACT:

Background

Acetylcholine (ACh) signalling mediated by muscarinic acetylcholine receptors (mAChRs) significantly influences various physiological functions, including muscle contraction. Among these receptors, the M₁ and M₂ subtypes are key modulators of neurotransmission at the neuromuscular junction (NMJ), acting through the protein kinase C (PKC) signalling pathway, critical for synaptic function. PKC phosphorylates essential synaptic vesicle-associated proteins such as Mammalian uncoordinated-18 (Munc18-1) and Synaptosome-associated protein of 25 kDa (SNAP-25), facilitating synaptic vesicle fusion and neurotransmitter release. Although neurotransmitter release at the NMJ is known to be coordinately regulated by both presynaptic nerve stimulation and retrogr

SUBMITTER: Polishchuk A 

PROVIDER: S-EPMC12522234 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature