ZNF655 promotes tumor growth and chemoresistance by targeting MAFF-CCND1 axis in ovarian cancer.

ABSTRACT: Ovarian cancer (OC) has the highest mortality rate among gynecological malignancies. The role of zinc finger protein 655 (ZNF655) in cancer progression has been highlighted but remains unclear and needs further exploration. In this study, our findings revealed that ZNF655 is aberrantly upregulated in OC. Depletion of ZNF655 inhibited the malignant behaviors of OC, manifested by attenuated proliferation, promoted apoptosis, inhibited migration and reduced stem cell properties. Mechanistically, ZNF655 facilitated nuclear translocation of MAFF transcription factor in OC cells, leading to MAFF's direct binding to the promoter of CCND1 and subsequent transcriptional activation of CCND1. Subsequent rescue experiments demonstrated that CCND1 plays a critical role in mediating ZFN655-dependent pro

SUBMITTER: Xiong Y 

PROVIDER: S-EPMC12522256 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature