Genetic investigation of sinopulmonary diseases in Vietnam: seeking specific causes from non-specific symptoms.

ABSTRACT:

Background

Sinopulmonary diseases are characterized by bronchiectasis (BE) and chronic rhinosinusitis, partly arising from clear genetic abnormalities such as cystic fibrosis (CF) and primary ciliary dyskinesia (PCD). However, the spectrum varies across ethnicities, and specifically, while considered rare in Southeast Asia, the current status in this region remains largely unknown. In this study, we investigated the clinical and genetic characteristics of patients with chronic symptoms affecting both the upper and lower airways in the northern region of Vietnam.

Results

We recruited 200 patients with chronic rhinosinusitis and productive cough in Vietnam. Clinical characteristics including pulmonary function measurements and high-resolution chest computed tomography findings

SUBMITTER: Phuong PT 

PROVIDER: S-EPMC12522257 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature