The role of insulin resistance in the longitudinal progression from NAFLD to cardiovascular-kidney-metabolic disease.

ABSTRACT:

Background and objective

This study aimed to elucidate the role of insulin resistance in the progression from non-alcoholic fatty liver disease (NAFLD) to cardiovascular-kidney-metabolic (CKM) diseases, and to explore the potential influence of lifestyle factors.

Methods

This study included participants free of NAFLD and CKM diseases from the UK Biobank. Insulin resistance was assessed using the TyG index. CKM diseases include ischemic stroke (IS), ischemic heart disease (IHD), type 2 diabetes (T2D), and chronic kidney disease (CKD). Markov multi-state models were used to assess the associations between the TyG index and disease transitions.

Results

Among 377,757 participants (median age 57 years), 4949 developed NAFLD over a median follow-up of 13.6 years. Of these,

SUBMITTER: Hou C 

PROVIDER: S-EPMC12522269 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature