Functional connectivity in whole-brain and network analysis differentiates minimally conscious from unresponsive patients: a resting-state fNIRS study.

ABSTRACT:

Background

Accurately assessing and detecting residual awareness in patients with vegetative state/unresponsive wakefulness syndrome (VS/UWS) and minimally conscious state (MCS) remains significant challenges. We aimed to investigate the whole-brain and network characteristics based on resting-state functional near-infrared spectroscopy (fNIRS) in patients with disorders of consciousness (DOC). Additionally, we sought to identify specific biomarkers to differentiate MCS from VS/UWS and evaluate their classification performance.

Methods

For DOC patients, the Coma Recovery Scale-Revised (CRS-R) assessment was conducted, and all participants underwent a 5-min resting-state fNIRS recording. Functional connectivity features based on region of interest, channel, and network analys

SUBMITTER: Wu S 

PROVIDER: S-EPMC12522307 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature