Identification and validation of aryl hydrocarbon receptor-associated hub genes in ulcerative colitis via integrated bioinformatics analysis.

ABSTRACT:

Objective

Ulcerative colitis (UC), a chronic inflammatory bowel disease, continues to pose substantial challenges in both diagnosis and treatment. The aryl hydrocarbon receptor (AhR) plays a pivotal role in intestinal immune regulation; however, its core regulatory network in the progression of UC remains largely undefined. This study aims to identify core UC-related genes associated with AhR and to validate their expression in dextran sulfate sodium (DSS)-induced murine models, thereby elucidating potential mechanisms underlying UC progression.

Methods

Using the GSE75214 and GSE87466 datasets from the Gene Expression Omnibus (GEO) database, immune cell infiltration was quantified via the CIBERSORT algorithm. Candidate genes were identified through differential expression an

SUBMITTER: Zhao Y 

PROVIDER: S-EPMC12522315 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature