Association of vitamin D receptor mRNA expression, vitamin D deficiency and genetic variant in patients with multi-drug resistant pulmonary tuberculosis.

ABSTRACT:

Background

Multi-drug resistant pulmonary tuberculosis (MDR-TB), is a serious threat to world health. Serum levels of vitamin D, a ligand for the VDR that controls VDR mRNA expression, are still poorly understood in MDR-TB.

Objective

To study the association of mRNA expression with low vitamin D levels and VDR polymorphisms in patients with MDR-TB compared to normal controls.

Methods

Study groups consisted of sputum smears and culture-positive MDR-TB at two hospitals in New Delhi, and normal controls were enrolled from a North Indian population. A total 100 (50 MDR-TB subjects and 50 controls) were consecutively enrolled. VDR mRNA expression in peripheral blood mononuclear cells (PBMC) was analysed by Real-time PCR. Serum 25-hydroxyvitamin D, intact parathyroid hormon

SUBMITTER: Rathored J 

PROVIDER: S-EPMC12522335 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature