Exome sequencing reveals new insights into the germline landscape of inflammatory breast cancer among Tunisian patients.

ABSTRACT:

Background

Inflammatory breast cancer (IBC) is a rare and aggressive form of breast cancer, characterized by distinct clinicopathological features and a relatively high frequency in North African countries. While several studies have explored the genetic basis of breast cancer, limited research has looked into the specific genetic features of this aggressive form. This study aims to investigate the genetic factors associated with IBC in North Africa, particularly among Tunisian patients.

Methods

Whole exome sequencing was performed for 13 patients with IBC. Clinicopathological data have been collected to assess the phenotype-genotype correlation. Both germline point mutations and copy number variations (CNVs) were analyzed. Genes and variants were prioritized through phenoty

SUBMITTER: Boujemaa M 

PROVIDER: S-EPMC12522356 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature