A multidisciplinary management model for severe gestational hypertriglyceridemia: using plasmapheresis to prevent pancreatitis in pregnancy.

ABSTRACT: Severe gestational hypertriglyceridemia can lead to life-threatening pancreatitis with high maternal and fetal mortality, yet there are no established guidelines for managing these patients. We report two cases of severe gestational hypertriglyceridemia managed through a multidisciplinary approach. With the collaboration of obstetricians, endocrinologists, and nephrologists, we utilized a novel plasmapheresis circuit-combining centrifugation and filtration plasmapheresis (CFPP)-and performed regular sessions via peripheral venous access without the use of plasma or albumin. This treatment effectively lowered triglycerides in an attempt to prevent gestational pancreatitis, with no major maternal or fetal complications. We also conducted a systematic review of published reports on regular ap

SUBMITTER: Zheng X 

PROVIDER: S-EPMC12522368 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature