Melatonin administration attenuates fibrosis progression in frozen shoulder syndrome: a rat model study.

ABSTRACT:

Background

Frozen shoulder syndrome, or adhesive capsulitis, is characterized by pain and restricted joint mobility due to fibrotic changes within the shoulder joint capsule. Despite its potential for spontaneous resolution, persistent symptoms often necessitate further treatment. Melatonin, known for its anti-inflammatory and anti-fibrotic properties, has emerged as a promising therapeutic agent for this condition. This study aimed to investigate the impact of melatonin on adhesive capsulitis in a rat model, focusing on its potential to attenuate fibrosis progression and improve joint pathology.

Methods

Thirty female Sprague-Dawley rats were utilized in this study. Frozen shoulder syndrome was surgically induced, and the rats were divided into three groups: G1 receiving a m

SUBMITTER: Gurbuz S 

PROVIDER: S-EPMC12522404 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature