Age and sex influence diurnal memory oscillations, circadian rhythmicity, and Per1 expression.

ABSTRACT:

Background

The circadian system influences many different biological processes across the lifespan, including memory performance and daily activity patterns. The biological process of aging causes decreased control of the circadian system that is accompanied by a decline in memory performance, suggesting that these two processes may be linked. Indeed, our previous work has shown that in male mice, the clock gene Per1 functions within the dorsal hippocampus to exert diurnal control over memory and repression of Per1 in the old hippocampus contributes to age-related impairments in spatial memory. Although it is clear that Per1 may be a key molecular link between memory and the circadian rhythm, next to nothing is known about how sex impacts this role in the young or old brain. Here,

SUBMITTER: Bellfy L 

PROVIDER: S-EPMC12522461 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature