Gut microbiota remodeling and sensory-emotional functional disruption in adolescents with bipolar depression.

ABSTRACT:

Background

Adolescence is the peak period of newly-onset bipolar disorder (BD). Accumulating studies have revealed disturbed gut microbiota can interfere with neurodevelopment in adolescents. In this study, we aimed to characterize the gut microbiota in adolescents with BD and its correlation with brain dysfunction.

Methods

Thirty unmedicated BD adolescents within depressive episode were recruited and underwent four-week quetiapine treatment. Twenty-five age-, gender-, and BMI-matched healthy controls (HCs) were recruited. Fecal samples were collected from HCs and all BD adolescents before and after treatment and analyzed by metagenomic sequencing. Resting-state cranial functional magnetic images were collected from 21 BD adolescents before treatment. Random forest models we

SUBMITTER: Tang A 

PROVIDER: S-EPMC12522507 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature