Cardiopulmonary crosstalk in Long COVID: a systematic review of emerging evidence.

ABSTRACT:

Background

Long COVID is a complex, multisystem syndrome with significant cardiopulmonary implications. Persistent inflammation, endothelial dysfunction, and microvascular injury contribute to prolonged symptoms such as dyspnea, chest pain, and exercise intolerance. Despite growing recognition of these complications, the underlying mechanisms of cardiopulmonary interactions remain poorly understood.

Methods

A comprehensive literature search was conducted on PubMed, Scopus, Google Scholar, and Web of Science covering studies from 2019 to 2025. Keywords included "Long COVID", "cardiopulmonary interaction", "pulmonary fibrosis", "myocardial inflammation", and "endothelial dysfunction". A total of 102 articles were included, comprising 65 original research studies and 37 review

SUBMITTER: Arab Z 

PROVIDER: S-EPMC12522509 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature