Oral anticoagulation in patients with gastrointestinal bleeding and new-onset atrial fibrillation: A population-based registry-linkage study.

ABSTRACT:

Background

Limited data exist on the prevalence of gastrointestinal bleeding (GIB) in patients with new-onset atrial fibrillation (AF) and the impact of GIB on the initiation of oral anticoagulation (OAC) therapy.

Methods

A population-based registry-linkage study included all patients diagnosed with new-onset AF in Finland during 2010-2018 who had available laboratory data and a definite indication for OAC therapy. The primary outcome was OAC initiation within 90 days following AF diagnosis. Factors associated with OAC initiation were assessed using modified Poisson regression.

Results

Among 117 997 patients with new-onset AF, 6628 (5.6%) had GIB, of which 5336 occurred more than 30 days prior to AF diagnosis, and 1292 were temporally (±30 days) associated with new-on

SUBMITTER: Jolkkonen S 

PROVIDER: S-EPMC12522523 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature