Albuminuria is associated with increased risk of dementia, independent of eGFR: The SCREAM project.

ABSTRACT:

Background

The association between albuminuria and dementia has been insufficiently studied, possibly due to not considering dementia subtypes, the interplay with estimated glomerular filtration rate (eGFR), and the use of varying albuminuria measurement techniques.

Objectives

This study aimed to investigate the eGFR-independent risk of all-cause and type-specific dementia associated with albuminuria, measured by the urine albumin-creatinine ratio (ACR) and dipstick.

Methods

The main analysis included 132,869 subjects aged ≥65 years without a history of dementia and with at least one ACR test from the Stockholm Creatinine Measurements (SCREAM) project between 2006 and 2019. The primary and secondary outcomes were the incidence of all-cause dementia and type-specific d

SUBMITTER: Luo L 

PROVIDER: S-EPMC12522533 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature