β-Adrenergic Receptor Activation Modulates the Induction of Complex Spike-Dependent LTP by Regulating Multiple Forms of Heterosynaptic Plasticity.

ABSTRACT: Norepinephrine, acting through β-adrenergic receptors (β-ARs), has a key role in hippocampus-dependent forms of learning. Although β-AR activation also facilitates the induction of Hebbian LTP, recent findings indicate that a non-Hebbian form of synaptic plasticity, known as behavioral timescale synaptic plasticity (BTSP), underlies hippocampus-dependent spatial learning. To explore the role of noradrenergic signaling in BTSP, I investigated the effects of the β-AR activation on complex spike (CS) burst-dependent LTP, a form of BTSP induced by theta-pulse stimulation (TPS) protocols in the CA1 region of mouse hippocampal slices. β-AR activation not only enhanced the homosynaptic potentiation of synaptic transmission induced by TPS but also modulated heterosynaptic forms of plasticity criti

SUBMITTER: O'Dell TJ 

PROVIDER: S-EPMC12522536 | biostudies-literature | 2025 Nov

REPOSITORIES: biostudies-literature