REACT SHOCK trial protocol and analysis plan-a multicenter randomised controlled trial comparing individualised blood pressure target versus standard blood pressure target among critically ill patients with shock.

ABSTRACT:

Background

Critically ill patients with shock receiving vasopressor or inotrope therapy in ICU are often exposed to relative hypotension, which is quantified as percentage blood pressure deficit relative to usual pre-illness blood pressure. Whether minimising such blood pressure deficit, by adjusting blood pressure targets according to patients' pre-illness blood pressure (individualised blood pressure target strategy), can improve clinical outcomes remains unclear. Therefore, we are conducting a multicenter randomised controlled trial, the REACT SHOCK RCT, comparing individualised blood pressure targets to standard care among critically ill patients with shock.

Methods

The REACT SHOCK RCT is an international, multicenter, parallel-group, randomised, standard-care controlled

SUBMITTER: Panwar R 

PROVIDER: S-EPMC12522556 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature