Bactericidal activity and Inhibition of levofloxacin-induced resistance by antibacterial combination against hypervirulent Klebsiella pneumoniae.

ABSTRACT:

Background

Hypervirulent Klebsiella pneumoniae (hvKP) infection is characterized by its potential severity and metastatic propensity, underlying the importance to employ bactericidal treatment promptly for infection source control. The aim of this study is to investigate the bactericidal activity of antibacterial combination against hvKP, with a particular focus on whether levofloxacin-based combinations can suppress levofloxacin-induced efflux pump related drug resistance.

Methods

We conducted in vitro antimicrobial susceptibility tests on 12 hvKP clinical isolates and the reference strain NTUH-K2044. Checkerboard assays were conducted to evaluate the combination activity of levofloxacin with amikacin or ceftazidime. Time-kill experiments were performed to determining the b

SUBMITTER: Aimaiti A 

PROVIDER: S-EPMC12522571 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature