Recruitment and retention in a preclinical AD trial: comparisons between academic and non-academic sites.

ABSTRACT:

Background

Alzheimer's disease (AD) clinical trials enroll participants at various site types including research-focused academic institutions and independent non-academic sites. Limited research has examined the impact of site type on recruitment and retention outcomes.

Methods

To evaluate potential differences between site types, we used data from the Anti-Amyloid Treatment for Asymptomatic AD (A4) trial, the largest completed preclinical AD trial to date. We first compared the frequency of varying recruitment sources between site types. We then examined potential differences in participant- and site-level characteristics. To assess potential site type differences in retention, we fit a multivariable logistic regression model adjusting for variables associated with site ty

SUBMITTER: Ritchie M 

PROVIDER: S-EPMC12522582 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature