Zinc finger protein Zfp335 is required for T cell homeostatic proliferation through regulating Lmnb1.

ABSTRACT:

Background

T cell homeostasis is crucial for maintaining T cell population size and upcoming protective immunity in the peripheral organs. However, it remains largely unknown about the intracellular molecules and pathways beyond IL-7R signaling. Zfp335, as a key transcription factor, is involved in the multiple-stage development of thymocytes, and effector and memory T cell differentiation during immune responses.

Results

In current study, we found an upregulated expression of ZFP335 in both CD4⁺ and CD8⁺ T cells during peripheral homeostasis. In an adoptive transfer model, Zfp335^-/- T cells failed to undergo homeostatic proliferation without survival defect. Consistently, deletion of Zfp335 impaired T cell proliferation in in vitro culture w

SUBMITTER: Yang B 

PROVIDER: S-EPMC12522623 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature