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Efficacy and safety of tranexamic acid in cardiac surgery: a systematic review and network meta-analysis.


ABSTRACT:

SUBMITTER: Pan X 

PROVIDER: S-EPMC12522650 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature

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Efficacy and safety of tranexamic acid in cardiac surgery: a systematic review and network meta-analysis.

Pan Xiaoli X   Tang Mingxuan M   Xu Zhao Z   Yu Hong H   Huang Jiapeng J   Liang Peng P  

BMC anesthesiology 20251014 1


BACKGROUND: Tranexamic acid (TXA) is recommended for reducing blood loss and transfusion in cardiac surgery. However, there are concerns regarding the safety profile of TXA, especially its proconvulsant effects. We conducted this study to investigate the efficacy and safety of tranexamic acid in cardiac surgery. METHODS: We searched PubMed, Embase and Cochrane Central Register of Controlled Trials from inception to December 11, 2024. Randomised controlled trials assessed the hemostatic effects o  ...[more]

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