ApoJ and apoL1 as novel determinants of MASH: a cross-sectional study.

ABSTRACT:

Background

Plasma apolipoproteins are linked to cardiometabolic dysfunctions, but their potential as biomarkers for metabolic dysfunction-associated steatohepatitis (MASH) remains underexplored.

Methods

Plasma levels of 14 apolipoproteins (apoA-I, A-II, A-IV, B100, C-I, C-II, C-III, D, E, F, H, J, L1, M) were quantified using liquid chromatography-tandem mass spectrometry in a cross-sectional study of 148 individuals with obesity undergoing bariatric surgery. Based on liver histology, participants were categorized as non-MASH (n = 94; no liver alterations or simple steatosis, ≥ 5% intrahepatic fat) or MASH (n = 54; steatosis with ballooning and lobular inflammation, with or without fibrosis). Correlations with clinical and biochemical parameters were assessed via Spearman's

SUBMITTER: Cai Z 

PROVIDER: S-EPMC12522655 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature