Association of cardiometabolic risk burden with gastrointestinal bleeding in aspirin users.

ABSTRACT:

Introduction

Aspirin is widely used in patients with ischemic cardiovascular diseases, most of whom have cardiometabolic disorders. This study aimed to investigate the impact of cardiometabolic risk burden on first gastrointestinal (GI) bleeding in aspirin users.

Methods

This is a cohort study, including patients with ischemic cardiovascular disease and aspirin prescription from UK biobank. Exposure was cardiometabolic risk burden, calculated as the sum of the presence of cardiometabolic risk factors, including obesity, diabetes, dyslipidemia and hypertension. GI bleeding obtained from hospital inpatient admissions was the outcome. The Cox proportional hazards model was used to calculate the hazard ratio (HR) and 95% confidence interval (CI).

Results

After a mean of 1

SUBMITTER: Wei Y 

PROVIDER: S-EPMC12522657 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature