Exploring the association between ceramide, phosphatidylcholine, and COPD prevalence and incidence: a FINRISK population-based cohort study.

ABSTRACT:

Background

Ceramides (Cers) and phosphatidylcholines (PCs) are potential lipid biomarkers in obstructive pulmonary disease (COPD). Even though they are linked to inflammation and lipid dysregulation, little is known about how these factors affect the prevalence and incidence of COPD in population-based cohorts. This study investigates these associations, addressing knowledge gaps regarding the interplay of Cers, PCs, and COPD risk, focusing on sex-specific differences and smoking.

Methods

This observational study analysed data from the population-based FINRISK 2002 cohort, with 7,722 participants for prevalence and 7,662 for incidence analyses. Logistic regression models were used to assess associations between lipid biomarkers and prevalent COPD, while Cox regression models

SUBMITTER: Shoghli M 

PROVIDER: S-EPMC12522678 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature