Aberrant alternative splicing in alcoholic hepatitis: regulatory roles of RBPs and sQTLs.

ABSTRACT:

Background

Alternative splicing (AS) plays a critical role in gene regulation, contributing to transcriptomic complexity and disease progression.

Methods

In this study, we investigated the regulatory effects of AS in alcoholic hepatitis (AH) using transcriptomic data from 41 samples (Normal: 21; AH: 20) from three projects (PRJNA597328, PRJNA600011 and PRJNA656197) from the NCBI database.

Results

A total of 1,061,774 transcripts were identified, of which 42.23% were novel and not annotated in the reference genome, highlighting the diversity of transcriptomic variation in AH. Furthermore, we identified 1,655 aberrant alternative splicing events (AASEs) associated with 1,170 genes, 487 of which were significantly correlated with 22 differentially expressed RNA-binding p

SUBMITTER: Zhao J 

PROVIDER: S-EPMC12522691 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature