Circulating endothelial signatures correlate with worse outcomes in COVID-19, respiratory failure and ARDS.

ABSTRACT:

Background

Elevated circulating endothelial cells (CECs), released from monolayers after insult, have been implicated in worse outcomes in ARDS and COVID-19, however there is no consensus proteomic phenotype that define CECs. We queried whether a transcriptomic approach would alternatively support the presence of endothelial cells in circulation and correlate with worsening respiratory failure.

Methods

To test whether elevated endothelial cell signatures (ECS) in circulation plays a role in worse respiratory outcomes, we used unsupervised bulk-transcriptome deconvolution to quantify ECS% in two cohorts. Our pilot analysis included pediatric patients requiring invasive mechanical ventilation (CAF-PINT, NCT01892969). Our validation cohort included adult hospitalized patients w

SUBMITTER: Costa Monteiro AC 

PROVIDER: S-EPMC12522733 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature