Exploring a gene co-expression network throughout the trypanosoma cruzi life cycle.

ABSTRACT:

Background

Trypanosoma cruzi, the causative agent of American trypanosomiasis (Chagas disease), is a protozoan parasite with a complex life involving multiple developmental stages in both its triatomine vector and mammalian host. Each stage is characterized by distinct morphological and functional traits. Intriguingly, T. cruzi exhibits polycistronic transcription, relying predominantly on post-transcriptional mechanisms for gene regulation.

Methods

To delve deeper into the molecular aspects of this regulation, we performed gene co-expression network (GCN) analysis using transcriptomic data spanning all life-cycle stages of T. cruzi, offering insights into the coordinated expression patterns of functionally Linked gene groups. We examined the global network properties, ident

SUBMITTER: Inchausti L 

PROVIDER: S-EPMC12522734 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature