PEGylation of liposome-encapsulated midazolam does not improve the bioavailability of midazolam when administered orally.

ABSTRACT:

Background

Liposomes are closed vesicles made of the same phospholipid bilayer as biological membranes and are capable of containing drugs, and so they have been investigated as useful drug carriers for drug delivery. We previously developed liposome-encapsulated midazolam (LE-midazolam) for oral administration, but midazolam is metabolized in the liver, and for clinical use the encapsulation of the liposomes needed to be improved to increase the bioavailability of midazolam. The surfaces of pharmaceutical liposomes are generally coated with polyethylene glycol (PEGylation) because it prevents their capture by phagocytes and helps them to avoid the reticuloendothelial system. Therefore, we considered that PEGylation could reduce the metabolism of orally administered encapsulated mi

SUBMITTER: Nishioka Y 

PROVIDER: S-EPMC12522756 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature