Helicobacter pylori infection impairs glucose homeostasis through gut microbiota dysbiosis.

ABSTRACT:

Background

Epidemiological data show that Helicobacter pylori (H. pylori) infection is not only the most important risk factor for gastric cancer, but is also associated with poor glycemic control in patients with diabetes. However, the direct causal and functional relationship between H. pylori infection and dysglycemia is unclear.

Method

A retrospective cohort study was conducted to examine the association between H. pylori infection and glycemic levels in individuals with Type 2 diabetes. C57BL/6 diabetic mice were infected with H. pylori, and the resulting changes in colonic inflammation and intestinal Glucagon-like peptide-1 (GLP-1) secretion were thoroughly examined using immunohistochemistry, RNA sequencing, metagenomic sequencing, and targeted metabolomics. The micro

SUBMITTER: Chen H 

PROVIDER: S-EPMC12522810 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature