BMAL1 alleviates sepsis-induced acute kidney injury by inhibiting apoptosis, ferroptosis and inflammation.

ABSTRACT:

Background

Sepsis is a life-threatening syndrome characterized by organ dysfunction. The kidney is one of the earliest organs to be injured during sepsis. Basic Helix-Loop-Helix ARNT Like 1 (BMAL1) was shown to play a critical role in immune responses. BMAL1 deregulation is related to sepsis-induced injury. Thus, correct understanding of the molecular mechanism of BMAL1 in sepsis-induced acute kidney injury (AKI) may be importance for seeking effective targeted therapy.

Methods

Lipopolysaccharide (LPS)-induced renal tubular epithelial cells (HK-2 cells) and a sepsis-AKI model established in C57BL/6 mice using cecal ligation and puncture (CLP) were used for functional analyses. In vitro analyses were conducted using EdU assay, flow cytometry, MTT assay and ELISA, respectively

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12522825 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature