Jianpi Qutan Decoction improves hepatic lipid metabolism in atherosclerosis mice via PPARα-CPT1α pathway regulation.

ABSTRACT:

Objective

To investigate Jianpi Qutan Decoction (JPQT)'s effects on hepatic lipid metabolism via the PPARα-CPT1α pathway.

Methods

Eight male C57BL/6J mice served as controls; 32 ApoE^-/- mice were randomized into atherosclerosis (AS), atorvastatin calcium (AC), and low/medium/high-dose JPQT groups. Prior to the intervention, therapeutic targets of JPQT were analyzed using network pharmacology to provide a theoretical basis for subsequent experiments. The AS model was induced by a 12-week high-fat diet. Hepatic triglyceride (TG) and cholesterol (TC) were measured via GPO-PAP. Glucose tolerance (GTT) and insulin tolerance (ITT) were assessed. Pro-inflammatory cytokines were analyzed by ELISA/colorimetry. Fatty acid metabolism enzymes were evaluated using kits. PPARα-

SUBMITTER: Gao X 

PROVIDER: S-EPMC12522855 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature