The APOE ε4 allele affects the survival of patients with Parkinson's disease independent of dementia.

ABSTRACT:

Background

Patients with Parkinson's disease (PD) tend to have a shorter life expectancy compared to the general population. While the genetic architecture significantly influences individual variability in survival among these patients with PD, the contributions of most genetic variations to this heterogeneity remain unclear.

Methods

The study included 2365 living and 1575 deceased unrelated White European PD patients from the UK Biobank, of whom 503 had PD as the primary cause of death and 423 had PD as the secondary cause of death. Consequently, a genome-wide time-to-event analysis, utilizing a saddle point approximation implementation based on the Cox proportional hazards regression model, was performed to identify variants associated with the survival time of PD patient

SUBMITTER: Wang Z 

PROVIDER: S-EPMC12522874 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature