Angiopoietin-like protein 8 orchestrates macrophage glycogen metabolism and polarization via the JNK signaling pathway in cytokine storm syndrome.

ABSTRACT: Cytokine storm syndrome (CSS) is associated with severe damage and high mortality in acute diseases. Over-activation of M1 macrophages, accompanied with excessive pro-inflammatory cytokine secretion, drives cytokine storms, while promoting M2 macrophage polarization is a potential CSS treatment. The liver, an immune-responsive organ, secretes hepatokines such as fibroblast growth factor-21 (FGF-21) to regulate macrophage activation, but knowledge of their role in CSS-related inflammation is elusive, fueling the search for new hepatokines that can effectively fine-tune the pro-inflammatory activation of macrophages during CSS. In this study, lipopolysaccharide (LPS)-induced CSS signals increase hepatic Angiopoietin-like protein 8 (Angptl8) expression. Angptl8 knockout (Angptl8^-/-

SUBMITTER: Su Y 

PROVIDER: S-EPMC12522911 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature