Transcriptomic analysis in peripheral blood mononuclear cells from hyper and hypo weight-loss responders.

ABSTRACT:

Background

Caloric restriction is so far the most effective strategy for weight management. Based on their weight loss response, individuals can be classified as hypo-responders or hyper-responders. Therefore, efforts have been made to understand the molecular mechanisms underlying these differential responses to develop more effective and personalized weight loss interventions. This study aimed to identify changes in gene expression patterns between hyper- and hypo-responders selected from a dietary intervention based on caloric restriction.

Results

At the end of the intervention, both groups showed reductions in all evaluated anthropometric parameters. However, the hyper-responder group lost 82.3% more weight, 81.5% more in BMI, 68.9% more in hip circumference, and 47.97%

SUBMITTER: Vela-Vasquez DA 

PROVIDER: S-EPMC12522912 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature