Population stratified differences between ATG16L1 rs2241880 polymorphism with Crohn's disease risk: a systematic review and meta-analysis.

ABSTRACT:

Background

ATG16L1 rs2241880 (T300A), a single-nucleotide variant, plays a controversial role in the development of Crohn's disease (CD).

Aim

This meta-analysis aimed to explore the association between rs2241880 and CD among different subgroups by collecting the largest sample size published so far.

Methods

We retrieved articles from China National Knowledge Infrastructure, PubMed, Web of Science, and Embase databases, adhered to the PRISMA 2020 guidelines. The correlation between the rs2241880 variant and CD was assessed with a combined effect size of the calculated 95% confidence interval (CI) and odds ratio (OR). Heterogeneity was assessed by the I² value among genetic models. Publication bias was tested using the Egger test and funnel plot.

Results</

SUBMITTER: Gao Y 

PROVIDER: S-EPMC12522927 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature