TRPM2: a pivotal player in tumor progression and a promising therapeutic target.

ABSTRACT: TRPM2, a member of the TRPM family, is a ubiquitously expressed non-selective cation channel located on cellular membranes. Activated by ADP-ribose (ADPR), this channel is prevalent across various normal tissues and plays a critical role in numerous physiological and pharmacological processes, particularly in maintaining calcium homeostasis. A substantial body of evidence indicates that elevated expression of TRPM2 is associated with various cancer types. Increased TRPM2 expression has been significantly correlated with enhanced cellular proliferation, invasion, and poor prognosis in cancer patients. Furthermore, TRPM2 is pivotal in regulating Ca²⁺ levels, maintaining the mitochondrial function, and inducing cell cycle arrest, all contributing to tumor progression. This review e

SUBMITTER: Chen Z 

PROVIDER: S-EPMC12522950 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature