Impact of liver cirrhosis on health-related quality of life in Indian patients: interplay of disease severity, alcohol dependence, and malnutrition.

ABSTRACT:

Background

Liver cirrhosis (LC) significantly impairs health-related quality of life (HR-QoL) due to physical, psychological, and nutritional challenges. Despite its growing burden in India, limited evidence exists on how disease severity, alcohol dependence, and malnutrition influence HR-QoL in Indian LC patients.

Methods

This cross-sectional study included 565 LC patients attending a tertiary care hospital over 30 months. HR-QoL was assessed using SF-36. Disease severity was graded using the Child-Turcotte-Pugh (CTP) score, while nutritional status and alcohol dependence were evaluated using the RFH-NPT and AUDIT tools. Associations were analysed using Pearson's correlation, ANOVA, and logistic regression.

Results

The mean age of participants was 42.5 ± 14.9 years;

SUBMITTER: Singh AK 

PROVIDER: S-EPMC12522954 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature