Efficacy of artesunate-amodiaquine for the treatment of uncomplicated Plasmodium falciparum malaria among children aged 2-11 years in the Asante Akim North Municipality, Ghana: a single-arm open trial.

ABSTRACT:

Background

The burden of malaria in Ghana is significantly high. The emergence of resistance to artemisinin-based combination therapy (ACT), the primary treatment for malaria, necessitates constant surveillance. In this study the efficacy of artesunate-amodiaquine (AS-AQ), a first-line treatment for uncomplicated malaria in Ghana since 2005, and the prevalence of single nucleotide polymorphisms (SNPs) in resistance markers associated with this antimalarial drug were assessed.

Methods

This prospective single-arm trial was conducted between July 2018 and June 2019 at two health facilities. A total of 173 children aged 2-11 years who presented with fever or a history of fever and tested positive by rapid diagnostic test (RDT) were recruited for the study. The participants were

SUBMITTER: Hanson H 

PROVIDER: S-EPMC12522964 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature