Allostatic load and kidney cancer incidence and mortality: a genetic susceptibility and proteomic mediation analysis.

ABSTRACT:

Background

Allostatic load (AL), reflecting chronic physiological stress across neuroendocrine, immune, and metabolic systems, may contribute to the onset and prognosis of multiple cancers via inflammation and stress-related injury. However, the associations between AL and kidney cancer (KC) remain unclear. And large-scale evidence linking AL to KC risk, prognosis, and molecular mechanisms is lacking.

Methods

In this Prospective UK Biobank cohort study, 334,754 Participants were analyzed for KC incidence, 357 KC Patients for mortality, and 36,120 participants for proteomic mediation. Proteomic mediation was performed using Med4way analysis; protein trajectories were analyzed using locally weighted regression smoothing (LOESS) regression. The expression profiles of key mediat

SUBMITTER: Xu C 

PROVIDER: S-EPMC12523015 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature