Fluorene derivatives as potent antifungal and antibiofilm agents against fluconazole-resistant <i>Candida albicans</i>.

ABSTRACT: Candida albicans ranks as one of the most common causes of fungal sepsis in hospitalized patients around the world with an increasing mortality rate. The current antifungal drugs in use face several limitations including fungal resistance due to biofilm formation. This has complicated the treatment landscape, necessitating the need for continued search for effective therapeutic options against drug-resistant C. albicans threats. Therefore, this study investigated eighteen fluorene derivatives for their antifungal and antibiofilm potential against C. albicans. Two fluorene derivatives namely: 9,9-bis(4-hydroxyphenyl) fluorene (BHPF) and fluorene-9-acetic acid (FAA) were identified as potential inhibitors of Candida biofilms, achieving 97 % and 89 % inhibition at

SUBMITTER: Faleye OO 

PROVIDER: S-EPMC12523049 | biostudies-literature | 2025 Dec

REPOSITORIES: biostudies-literature