Effects of exercise alone or combined with dietary restriction on leptin and adiponectin in overweight or obese individuals: a network meta-analysis.

ABSTRACT:

Objective

This study aimed to evaluate the effects and ranking of different exercise modalities, with or without dietary restriction, on adipokine levels (leptin and adiponectin) in overweight and obese individuals. Additionally, the independent contribution of dietary restriction to adipokine level improvement was analyzed.

Methods

A systematic search of randomized controlled trials (RCTs) published between January 2000 and November 2024 was conducted in Cochrane Library, Embase, PubMed, Web of Science, and EBSCO databases. A network meta-analysis (NMA) was performed to integrate the results.

Results

A total of 87 RCTs were included. The regulatory effects of different exercise modalities and their combinations with dietary restriction on adipokine levels varied. Nea

SUBMITTER: Xin X 

PROVIDER: S-EPMC12523059 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature