Early-life exposure to tobacco smoke increase risk of frailty in adulthood: evidence from a large prospective cohort study.

ABSTRACT:

Background

Early-life exposure to tobacco smoke has been associated with various adverse health outcomes and is considered as a critical public health concern now. However, its impact on frailty risk remains unclear. This study aimed to investigate the association between early-life exposure to tobacco smoke and frailty in adulthood, and to assess whether this association is independent of cumulative smoking exposure and mediated by systemic inflammation and telomere length.

Methods

Participants were recruited from the UK Biobank. Early-life exposure to tobacco smoke was assessed using two measurements: in utero tobacco smoke exposure (IUTSE) and age of smoking initiation (ASI). Frailty was evaluated by frailty index and physical frailty, respectively. Ordered logistic regre

SUBMITTER: Li Z 

PROVIDER: S-EPMC12523062 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature