A scheme to navigate "biomolecule X" from Platycladi Folium against hepatocellular carcinoma via phytoinformatics.

ABSTRACT:

Background

Platycladi Folium (PF) is a natural herbal plant and a significant resource with anti-cancer agents, including hepatocellular carcinoma (HCC). In this study, we applied a phytoinformatics approach to identify potential therapeutic components for HCC treatment.

Methods

The target(s) of PF-derived molecules detected by gas chromatography-mass spectrometry (GC-MS) were relieved from reliable public bioinformatics databases (Similarity Ensemble Approach; SEA, and Swiss Target Prediction; STP), and HCC-responding targets were identified through human disease databases (DisGeNET, and OMIM databases). Holistically, PF-molecules-targets-mechanisms (PMTM) network was constructed to elucidate their therapeutic relationships. Next, molecular docking test (MDT) was conducted

SUBMITTER: Oh KK 

PROVIDER: S-EPMC12523066 | biostudies-literature | 2025 Oct

REPOSITORIES: biostudies-literature